A Breakthrough in Skin Anti-Aging

Introducing Hormesis C.A.R.E.
Cellular Anti-Aging Repair And Energy

Get C.A.R.E.

C.A.R.E. is the first product that targets the skin's biological aging in order to promote: 
Uniform complexion
Smoother skin
Diminished wrinkles
Visible lifting effect
Plump skin
Energized skin

HOW IT WORKS

Naturally Restoring Optimal Skin-Cell Function

While aging has many characteristics, decades of research points to the depletion of a key cellular resource called NAD+ as one significant factor, since NAD+ allows our cells to create energy and has been shown to have a crucial role in the manifestation of our longevity genes called Sirtuins. these Anti-Aging genes maintain the variety of processes essential for skin and body youthfulness. 

Between the ages of 40 and 60, we lose up to 50% of our NAD+. As NAD+ declines, our cells and Sirtuins lack the energy needed to maintain their original, youthful state.

C.A.R.E.
utilizes a breakthrough ingredient in skin anti-aging, called NR Nobel™, along with 10 supproting anti- aging ingredients, to help:
• Replenish NAD+ levels
• Increase cellular energy
production
• Stimulate Sirtuin activity
• Promote cellular repair
• Support youthful cellular
state

NR, NMN AND NAD+ FEATURED IN:

Before

After

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NR Nobel™

NR Nobel™ is a result of a two-year research performed by leading Israeli scientists from the Hebrew University and the Weizmann Institute of Science.

NR Nobel™ is a complex focusing on smart delivery of NR (Nicotinamide Riboside) and NMN (Nicotinamide Mononucleotide) molecules directly into the cell, where they are converted into NAD+.

Learn more about
NR Nobel™

Patented Enhanced Resveratrol

Discovered by Harvard Medical School, Resveratrol stimulates production of Sirtuins. As Resveratrol is fermented, the enzymes that are used in the process perform the work required for the skin to enjoy Resveratrol’s full benefits, giving the fermented Resveratrol greater strength and bio availability.

Learn more about Advanced Resveratrol
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Astragaloside IV 

Helps promote collagen synthesis, resulting in a younger and more vibrant looking skin 

Learn more about
Astragaloside IV

Matrixyl 3000™  Bio-Peptide

Researchers at the University of Reading in the United Kingdom have found that  Matrixyl 3000™ is able to double the amount of collagen in the skin and impart a smooth, fresh and healthy appearance by replenishing skin cells, softening, increasing moisture levels and restoring skin cells.

Learn more about
Matrixyl 3000™
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Co Enzyme Q10  

Co Q10 is of critical importance for the energy production of each tissue in our body and defense against free radicals .

Learn more about
Co Q10

PQQ

Pyrroloquinoline quinone, also called methoxatin, boosts cellular energy

Learn more about
PQQ
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Turmeric Extract 

Enhances skin appearance and promotes a glowing and healthy appearance 

Learn more about
Turmeric

Vitamin B Complex (B2/B5/B6/B12) 

This group of vitamins plays an important role in skin health, as well as helping maintain its appearance and delaying the aging process. 

Learn more about
Vitamin B Complex

Discover NR Nobel™

NR Nobel skin benefits 

Uniform complexion
Smoother skin
Diminished wrinkles
Visible lifting effect
Plump skin
Energized skin

NR molecule - beyond skin anti-aging

Improved cognition
Improved metabolism
Better sleep
Diseases treatment
Extends lifespan

NR Nobel™: An innovative breakthrough  in the field of life extension and its
application to skin Anti-Aging

NR Nobel™ is a result of a two-year research performed by leading Israeli scientists from the Hebrew University and the Weizmann Institute of Science.

NR Nobel™ is a complex focusing on smart delivery of NR (Nicotinamide Riboside) molecule directly into the cell, where it promotes proliferation of NAD+. When NAD+ concentration grows it catalyzes the manifestation of longevity genes called Sirtuins.

Latest researches in the field of life extension and longevity show that increasing NAD+ levels in the cell prevents age-associated metabolic decline and promotes longevity. NAD+ is found to have a decisive impact on vital processes including gene expression, cell cycle progression, insulin secretion, DNA repair, apoptosis and aging.

NR Nobel™ capsules

NR Nobel™ contains NAD+ fragments created by smart hydrolysis, among them are NR and NMN molecules which function as precursors of NAD+. The fragments are encapsulated to hydrophobic micro capsules, that can successfuly cross the epidermis. The capsules gradually disolve and the fragments make their way to the cells, penetrate cell nucleus, and raise NAD+ levels within the cells.

NR, NMN and NAD+ in scientific magazines

Nature

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.

Cell Metabolism:

Long-Term Administration of Nicotinamide Mononucleotide (NMN) Mitigates Age-Associated Physiological Decline in mice.

Frontiers in Biology:

Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD+ homeostasis and contributes to longevity.

Science:

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice.

NR, NMN and NAD+ research is backed by Nobel Prize winning scientists

How is it done:

NR (Nicotinamide Riboside), is a natural molecule existing in the human body, and can also be found in smaller doses in milk and beer. It is also used as a food additive and considered a super-food. NR functions as a precursor, and has the capability to raise NAD+ levels in cells.

Despite the fact that NAD+ itself can be produced, it cannot be incorporated into a cosmetic formula, and be applied directly onto the skin, becuase NAD+ is naturally generated only inside the cell. Alone, it cannot cross the intercellular barrier, and there are no pores (conexins) that allow the admittance of NAD+ into the cell.

NR Nobel™ resolves that issue by disintegrating NAD+ molecule into smaller molecules, and encapsulating the resulting complex into microcapsules that allow it to travel safely into the cell. Once inside, the complex is rebuilt back into NAD+.

Clinical Trial

The main focus of our clinical trial was to determine the safety of the active ingredient. The clinical trial lasted 40 days, in the course of which we were able to determine (a) the safety of the product, (b) its positive effect on overall skin condition. The clinical trial had been conducted by Dr. Ora Sheifer, a leading dermatologist.
35 female subjects between the ages of 65-35 were given a cream base substance for a period of 40 days of daily topical application. The trial was conducted double blind.

Group A - received cream base + NR        Group B - received placebo

Results

Safety: None of the patients reported any discomfort, irritation, abnormal sensation.
Overall condition: Uniform complexion, smoother skin, diminished wrinkles, a visible lifting effect, plumper skin.

Before

After

The Missing Piece in the Resveratrol Puzzle

discovered by Harvard Medical School, Resveratrol stimulates production of Sirtuins. Resveratrol is a naturally-occurring polyphenol antioxidant that is found in some plant products like grapes and cocoa.

However, In order to get the most benefits out of polyphenols, our bodies require specific enzymes. Enzymes break the polyphenols down into their most bioavailable form, concentrate them so that they're stronger and more effective, and purify them so they can do their work without irritating the skin.

Unfortunately, our skin does not produce these enzymes, reducing the effectiveness of topical Resveratrol, while increasing the risk of toxicity and irritation. Through a patented fermentation process, we make up the enzymes the skin lacks.

As Resveratrol is fermented, the enzymes that are used in the process perform the work required for the skin to enjoy Resveratrol’s full benefits, giving the fermented resveratrol greater strength and bioavailability.  

Astragaloside  IV

Astragalus membranaceus (Huangqi) is an important herb in traditional Chinese medicine, where it is used for the treatment of a variety of diseases and disorders and is marketed as a life-extending supplement for over 2000 years.

One of the major active components extracted from Astragalus membranaceus is Astragaloside IV, which has been found to decrease the rate of environmentally induced breakdown of collagen in the skin, especially due to ultraviolet radiation.

As we grow older, the balance between collagen damage and repair is disrupted, leading to the overall loss of collagen. Astragaloside IV helps restore skin collagen to a younger and more balanced state. 

Matrixyl 3000™

Researchers at the University of Reading in the United Kingdom have found that Matrixyl supports the creation of fibroblast molecules within the dermis and causes a significant improvement of existing wrinkles in addition to preventing future wrinkles. Matrixil is able to double the amount of collagen in the skin and impart a smooth, fresh and healthy complexion by replenishing skin cells, increasing moisture levels, and restoring skin health after exposure to sunlight and free radicals.

How does It work?
Matrixil is a bio-peptide, a tiny protein made up of amino acids capable of penetrating the skin's interior and intercellular tissue, where it supports intercellular communication while stimulating synthesis and repair of collagen and elastin fibers - proteins that support the skin structure and are essential for a smooth, wrinkle-free skin. 

Co-Q10

Co-enzyme Q10, naturally produced in our body and contributes to the activity of each cell in our body. It also acts as an antioxidant, Co-Q10 is found in the cell membrane and lipids on the skin surface and protects against free radicals inside and outside our cells. Free radicals damage cells and accelerate the aging process. Co-Q10 also protects the skin from the damage caused by UV sunlight.

The two most important roles of Co-Q10 in the human body are energy production and cellular protection.

American scientist Frederick L. Cran discovered Co-Q10 in 1957.

British chemist Peter Dennis Mitchell revealed how Q10 works inside the cells. He received a Nobel Prize in Chemistry for his work in 1978.

The effect of the Q10 enzyme on the skin Has been researched since 1998. 

PQQ

Skin aging starts at the cellular level and PQQ (pyrroloquinoline quinone) does an excellent job in protecting our cells, all while helping to improve the mitochondria-the powerhouse of our cells.
PQQ acts as an antioxidant in our body, protecting cells and their energy units- the mitochondria from the damage of free radicals. The more mitochondria we have in our skin-cells and the better they function, the more energy and vibrancy we can expect.

Turmeric Extract

Turmeric has been used in beauty treatments in ancient Indian medicine for centuries and plays a major in it's beauty rituals. To this day, Indian brides prepare for their wedding ceremony with turmeric masks, so that in their skin is fresh and glowing on their wedding day. 

The anti-inflammatory and antibacterial properties of turmeric make it an important component in our C.A.R.E. formula:

It helps protect the skin from free radicals responsible for skin aging and skin discoloration.

It regulates and balances the activity of the mammary glands and thus balances oily/dry skin.

Due to its anti-inflammatory activity, turmeric helps calm acne, eczema and redness.

It enhances the appearance of the skin imbuing it with a glowing and healthy appearance.

Vitamin B Complex (B2/B5/B6/B12)

This group of vitamins plays a vital role in proper skin health and function, in the prevention and treatment of various skin problems, such as dermatitis, acne and rosacea, as well as in maintaining the appearance of the skin and delaying its aging process.

Vitamin B2 (riboflavin) helps to calm the skin.

Vitamin B5 helps maintain the skin's moisture levels.

Vitamin B6 has been shown to have strong anti-oxidant effects and plays a crucial role in many cellular functions.

Vitamin B12 participates in the cell division process, including cells the undergo frequent division such as skin cells, which grow and regenerate rapidly at any given moment. For this reason, cells need sufficient vitamin B12 and other B vitamins to maintain normal growth. In addition, B12 has been found to help reduce skin redness, dryness and inflammation.

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