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Discover NR Nobel™
NR Nobel™ skin benefits
Visible lifting effect
NR molecule - beyond anti-aging
An innovative breakthrough in the field of life extension and its application to cosmetics
“NAD+ is the closest we’ve gotten to a fountain of youth,”
Prof. David Sinclair,
co-director of the Paul F. Glenn Center for
the Biology of Aging at Harvard Medical School.
NR Nobel™ is a result of a two-year research performed by leading Israeli
scientists from the Hebrew University and the Weizmann Institute of Science.
NR Nobel™ is a complex focusing on smart delivery of NR (Nicotinamide Riboside) molecule directly into the cell, where it promotes proliferation of NAD+. When NAD+ concentration grows it catalyzes the manifestation of longevity
genes called Sirtuins.
Latest researches in the field of life extension and longevity show that increasing NAD+ levels in the cell prevents age-associated metabolic decline and promotes longevity. NAD+ is found to have a decisive impact on vital processes including gene expression, cell cycle progression, insulin secretion, DNA repair, apoptosis and aging.
NR Nobel™ contains NAD+ fragments created by smart hydrolysis, among them are NR and NMN molecules which function as precursors of NAD+. The fragments are encapsulated to hydrophobic micro capsules, that can successfuly cross the epidermis. The capsules gradually disolve and the fragments make their way to the cells, penetrate cell nucleus, and raise NAD+ levels within the cells.
NR, NMN and NAD+ in scientific magazines
NR supplementation is well-tolerated in healthy middle-aged and older adults, and extend recent findings that acute supplementation with NR is effective for stimulating NAD+ metabolism in humans
Long-Term Administration of Nicotinamide Mononucleotide (NMN) Mitigates Age-Associated Physiological Decline in mice.
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice.
Turning back the cellular clock with NR led to the rejuvenation of mouse circadian rhythms and enhanced activity.
Many studies have revealed that administration of NAD precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), efficiently increase NAD levels in various tissues.
Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD+ homeostasis and contributes to longevity.
NR (Nicotinamide Riboside), is a natural molecule existing in the human body, and can also be found in smaller doses in milk and beer. It is also used as a food additive and considered a super-food. NR functions as a precursor, and has the capability to raise NAD+ levels in cells.
Despite the fact that NAD+ itself can be produced, it cannot be incorporated into a cosmetic formula, and be applied directly onto the skin, because NAD+ is naturally generated only inside the cell. Alone, it cannot cross the inter-cellular barrier, and there are no pores (conexins) that allow the admittance of NAD+ into the cell.
NR Nobel™ resolves that issue by disintegrating NAD+ molecule into smaller molecules, and encapsulating the resulting complex into micro-capsules that allow it to travel safely into the cell. Once inside, the complex is rebuilt back into NAD+.
The main focus of our clinical trial was to determine the safety of the active ingredient. The clinical trial lasted 40 days, in the course of which we were able to determine (a) the safety of the product, (b) its positive effect on overall skin condition. The clinical trial had been conducted by Dr. Ora Sheifer, a leading dermatologist.
35 female subjects between the ages of 65-35 were given a cream base substance for a period of 40 days of daily topical application. The trial was conducted double blind.
Group A - received cream base + NR Group B - received placebo
Safety: None of the patients reported any discomfort, irritation, abnormal sensation.
Overall condition: Uniform complexion, smoother skin, diminished wrinkles, a visible lifting effect, plumper skin.