The Biohacking Beauty Podcast
Biohacking Beauty Podcast
the death of anti-aging skincare & the longevity framework that replaces it
Your skin has a biological age and for most people, it's not the same as their chronological one. A leading scientific institution published the SkinSpan framework this year specifically to quantify it, and the 12 Hallmarks of Aging now have a direct application to dermal tissue. This raises an uncomfortable question: if you're already optimizing everything below the neck with NAD IVs, peptides, and red light, why is the skincare on your face still operating on a paradigm from 1987?In this new episode of the Biohacking Beauty Podcast, we give you a preview of the keynote we're delivering at Dave Asprey's Beyond Conference and walk you through the 3-pillar framework that replaces traditional anti-aging skincare with longevity science in mind. Because the results you can feel today and results you can measure in ten years are not the same thing. And we think you deserve both. Let's dive in.
the death of anti-aging skincare & the longevity framework that replaces it
Your skin has a biological age and for most people, it's not the same as their chronological one. A leading scientific institution published the SkinSpan framework this year specifically to...
the overlooked side of autophagy causing aging - part 2
The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy. In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body. We unpack why long-lived cells like fibroblasts and melanocytes depend on this cleanup process, what happens when it fails, and how it ties directly to gray hair, hyperpigmentation, sagging skin, and that brownish dullness no serum seems to fix. We also introduce one of the most overlooked players in this entire conversation, and explain why we believe it is the next NAD. If you want to understand what is actually happening underneath your skin as it ages, and what tools we have to intervene at the cellular level, this episode is for you.
the overlooked side of autophagy causing aging - part 2
The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your...
the overlooked side of autophagy causing aging - part 1
What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy. From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most people realize for skin aging. We explore the two master switches that control autophagy, mTOR and AMPK, and how the constant tug of war between them determines whether your cells are in build mode or cleanup mode. We also explain why most people in the modern world are stuck in permanent mTOR activation, and what that means for how their skin ages over time. This is Part 1 of our deep dive. In Part 2, we go skin-specific and break down exactly how autophagy renews your skin at the tissue level.
the overlooked side of autophagy causing aging - part 1
What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human...
Chris Mirabile: why one ingredient will never stop you from aging (and what actually does)
Most of what the supplement and skincare industry sells for aging targets one pathway at a time. But your biology does not age that way. It declines across 12 interconnected processes simultaneously, and by the time one of them shows up on your skin, the others have already been running for years. We at Young Goose believe that skin longevity is not a topical problem. It is a whole biology problem, and the ingredients you choose, how they interact, and whether anyone has actually tested them together matters more than any single molecule ever could. In this episode, we are joined for the second time around by Chris Mirabile, founder of NOVOS which is the first biotech company to target all 12 biological causes of aging. Chris collaborates with leading researchers at Harvard and MIT and has built his work around one premise: that real interventions require real testing on real humans, not just promising ingredients. Let's dive in.
Chris Mirabile: why one ingredient will never stop you from aging (and what actually does)
Most of what the supplement and skincare industry sells for aging targets one pathway at a time. But your biology does not age that way. It declines across 12 interconnected...
biohackers react to viral skintok videos on dermaroller, red light therapy wands & tretinoin
Most of what goes viral on SkinTok is missing one thing. The part where someone actually checks if it works. In this bonus episode, Amitay and Anastasia break down three of the most viral skincare trends circulating today, red light therapy wands, at-home dermarolling, and tretinoin, and run each one through a biohacker's lens. Not to dismiss them outright. But to ask the questions the original videos never do. What is actually happening at the cellular level? What are the real risks? And where does the marketing stop and the science start?
biohackers react to viral skintok videos on dermaroller, red light therapy wands & tretinoin
Most of what goes viral on SkinTok is missing one thing. The part where someone actually checks if it works. In this bonus episode, Amitay and Anastasia break down three...
real talk on motherhood, postpartum skin, and rebuilding from the inside out with Anastasia Khodzhaeva
Mothers sacrifice so much of themselves to carry another human being in their body for nine months. Even after childbirth, there's a phase called the fourth trimester because babies are still heavily dependent on moms for their survival. Motherhood looks different for every woman. For Anastasia, who is a first-time mom, motherhood looked particularly different since her family is overseas and she's also running Young Goose with Amitay. Yet, there's something unique when a biohacker becomes a mom that new moms can learn from. In this Young Goose Mother's Day Special, we celebrate every mother who gives selflessly to their family. We also take a peek into Anastasia's life as a new mom, what changed in her body and mindset, and how she maintained her self-care while taking care of the family and the business. This episode will make you realize that it takes a village to raise a kid, but it takes a great mom to raise a kid and still come back to herself. Because the only way she can show up fully for others is when she can show up for herself first.
real talk on motherhood, postpartum skin, and rebuilding from the inside out with Anastasia Khodzhaeva
Mothers sacrifice so much of themselves to carry another human being in their body for nine months. Even after childbirth, there's a phase called the fourth trimester because babies are...