About this collection

SpermIdine X Young Goose

As cells age, their ability to renew themselves slows down. A key reason for this is the decline of autophagy, the process by which cells find and break down damaged proteins and organelles, clearing the way for healthy function. Spermidine helps reactivate this process by suppressing EP300, an enzyme that can suppress autophagy.

When EP300 activity is reduced, cells can clear out waste more effectively, supporting energy production, and the biological processes that keep skin functioning well. Without this clearance, cellular waste accumulates, mitochondrial output drops, and the visible signs of aging worsen.

This is not cosmetic supplementation. It is biological optimization, addressing one of the twelve core drivers of cellular aging at the source.

Young Goose has incorporated CelVio® Spermidine into two formulas, Youth Reset and Youth Daily. Together, they form a protocol that targets autophagy and structural repair within a single daily routine.

  • YOUTH RESET

    YOUTH RESET

    YOUTH RESET

    Anti-Aging Serum

    $196.50 USD
    $196.50 USD
  • YOUTH DAILY

    YOUTH DAILY

    YOUTH DAILY

    Skin Longevity Moisturizer

    $176.50 USD
    $176.50 USD

Frequently Asked Questions

What is Spermidine, and why does it matter for skin?

Spermidine is a naturally occurring compound that helps reactivate autophagy, the process by which cells clear out damaged proteins and waste. As we age, EP300 enzyme activity suppresses this mechanism, causing waste to build up, and skin repair to slow. 

What is autophagy, and why does it slow down?

Autophagy is the process by which cells break down and recycle their own damaged components that would otherwise reduce cell function. 

In younger skin, this process runs properly, supporting collagen production and structural repair. As we age, rising EP300 activity progressively reduces autophagy, allowing cellular waste to gather. The effects include a weakened skin barrier and reduced firmness due to collagen breakdown.

CelVio® Spermidine is one of the few ingredients with demonstrated ability to suppress EP300 and reactivate this process, restoring the cellular conditions that support long-term skin health.

How do CelVio® Spermidine and NAD+ APEX™ work together?

CelVio® Spermidine and NAD+ APEX™ support cellular health through different but complementary pathways.

  • NAD+ APEX™ restores NAD⁺ levels, supplying the coenzyme that mitochondria require to produce energy and that PARP-1 requires to find and repair DNA damage.
  •  CelVio® Spermidine clears the cellular waste that impairs mitochondrial function and slows repair signalling, creating the clean cellular environment in which NAD+ APEX™ can work most effectively.

Together, they address two of the twelve biological drivers of skin aging: energy restoration and cellular clearance. 

How do I incorporate your products into my existing routine?

Youth Reset should be applied after cleansing, before moisturizer, as the first active step in your routine. Youth Daily follows as your daily moisturizer, locking in the actives delivered by Youth Reset and providing ongoing barrier support. 

For daytime use, finish with Bio-Shield SPF 40 to protect against UV-driven DNA damage that would otherwise counteract the cellular repair these formulas support. For a protocol tailored to your specific skin profile, use the Young Goose Skincare Quiz.

How long before I see results?

Because these formulas work at the level of cellular function, results follow biological timelines rather than cosmetic ones. The clearance of cellular waste and the restoration of structural repair processes are gradual by nature. Most users notice improvements in skin texture, firmness, and tone within 4–8 weeks of consistent daily use.