YOUTH ACTIVATION AMPOULE
YOUR 28-DAY PROTOCOL
Combine the powder and serum immediately before application.
Apply the complete contents of one ampoule evenly to your face and neck.
Use once daily. Evening is preferred, but morning works too. Always finish with sunscreen when used in the morning.
Apply after cleansing and any lightweight preparatory step, such as Blue Peptide Spray. Follow with moisturizer.
THE DUAL-CHAMBER DIFFERENCE
In a conventional water-based formula, some active ingredients can begin degrading long before they reach your skin. YOUTH ACTIVATION AMPOULE keeps key actives freeze-dried in a separate powder chamber until you are ready to apply them.
Keeping these ingredients dry reduces the risk of degradation and allows the formula to hold higher active concentrations.
Five peptides, NMN, ergothioneine, and supporting ingredients remain freeze-dried before use.
Pressing the bottom chamber releases the powder into the liquid serum.
Shaking dissolves the powder and combines both phases into one complete formula.
How the formula works
SIGNAL
Five peptides send targeted signals tied to expression lines, matrix organization, structural support, texture, and the processes involved in collagen breakdown.
FUEL
NMN in the dry chamber and niacinamide in the liquid provide two precursors to the skin’s NAD+ supply. NAD+ is a coenzyme cells rely on for energy-dependent functions, and its levels in human skin decline with age.
DEFEND
Ergothioneine is an antioxidant that cells draw in through a dedicated transporter. It helps manage the oxidative stress associated with cellular activity.
COMFORT
Humectants, acetyl glucosamine, and a film formed by tara fruit and red algae help maintain hydration and comfort through all 28 days.
UNDERSTANDING THE EVIDENCE
No clinical study has tested YOUTH ACTIVATION AMPOULE as a finished formula. The research presented here examines individual ingredients, ingredient classes, or other formulas, sometimes at different doses.
This evidence helps explain why each ingredient was selected and how the formula was built. It should not be interpreted as proof that YOUTH ACTIVATION AMPOULE will reproduce the results of any individual study.
HUMAN
Research conducted in human participants. When a different formula or dose was studied, we identify it.
CELL
Research conducted in cells in a laboratory. These findings help explain potential mechanisms and do not establish results in people.
IN SILICO
Computer modeling used to explore potential interactions or mechanisms. Predictions do not establish results in people.
REVIEW
Published reviews that bring together existing research. The strength and relevance of the evidence depend on the studies reviewed.
FORMULATION RATIONALE
The reasoning behind an ingredient’s inclusion in the formula. This is not a clinical test of the finished product.
UNDERSTANDING THE EVIDENCE
01 / 05
Hexapeptide-9
A collagen-derived signal peptide selected for the look of smoother lines and a more refined surface.
02 / 05
Acetyl Hexapeptide-8
Formulated toward the appearance of expression lines on the forehead, between the brows, and around the eyes.
03 / 05
Acetyl Tetrapeptide-9
Selected around signals involved in organizing the dermal matrix, the structural network that helps give skin its firm appearance.
04 / 05
Acetyl Tetrapeptide-11
Selected around cell-to-cell cohesion in the skin’s upper layers, where surface smoothness and evenness become visible.
05 / 05
Dipeptide Diaminobutyroyl Benzylamide Diacetate
Designed to address the other side of the matrix equation. In computer modeling, this peptide was predicted to bind several enzymes involved in collagen breakdown, including MMP-1, MMP-8, and MMP-13.
BEYOND THE PEPTIDE PANEL
CELLULAR FUEL
NAD+ is a coenzyme involved in the energy-dependent functions cells rely on. Research has found that NAD+ levels in human skin decline with age.
YOUTH ACTIVATION AMPOULE approaches that pathway with two precursors: NMN in the freeze-dried chamber and niacinamide in the liquid phase. Together, they provide two routes into the skin’s NAD+ supply.
More NMN than any other Young Goose formula.
HYDRATION + COMFORT
Glycerin, sodium hyaluronate, acetyl glucosamine, and a tara fruit and red algae film help attract and retain hydration. Collagen, orchid, and rockrose extracts in the dry chamber round out a system designed to keep skin comfortable throughout the course.
THE VISIBLE EXPERIENCE
WHERE IT FITS
Use one complete ampoule once daily for 28 consecutive days.
Evening is preferred, but it may also be used in the morning.
STEP 1
Begin with clean skin.
STEP 2
Apply a lightweight preparatory step, such as Blue Peptide Spray.
STEP 3
Freshly activate one ampoule, pour the full contents into your palm, and apply evenly to your face and neck.
STEP 4
Follow with your moisturizer.
STEP 5
If used in the morning, finish with sunscreen.
YOUTH ACTIVATION AMPOULE may be used on its own or alongside retinol. It contains no retinoid and does not create a retinization phase.
Store unopened ampoules at room temperature, away from direct light. Activate one ampoule only when you are ready to apply it, then use the complete contents immediately.
SCIENTIFIC REFERENCES
Chang H, Tao K, Yang Y, et al. “Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.” Journal of Cosmetic Dermatology. 2025;24(7):e70290. doi:10.1111/jocd.70290. PMID: 40586182.
Evidence type: Human study using a different form, formula, concentration, and protocol.
Massudi H, Grant R, Braidy N, et al. “Age-Associated Changes in Oxidative Stress and NAD+ Metabolism in Human Tissue.” PLOS ONE. 2012;7(7):e42357. doi:10.1371/journal.pone.0042357. PMID: 22848760.
Evidence type: Human observational study.
Betsuno R, Yamane T, Tsuji H, et al. “Permeation of Nicotinamide Mononucleotide (NMN) in an Artificial Membrane as a Cosmetic Skin Permeability Test Model.” Journal of Cosmetic Dermatology. 2025;24(5):e70222. doi:10.1111/jocd.70222. PMID: 40317586.
Evidence type: Artificial membrane and cell research using a different preparation.
Ko HJ, Kim J, Ahn M, et al. “Ergothioneine Alleviates Senescence of Fibroblasts Induced by UVB Damage of Keratinocytes via Activation of the Nrf2/HO-1 Pathway and HSP70 in Keratinocytes.” Experimental Cell Research. 2021;400(1):112516. doi:10.1016/j.yexcr.2021.112516. PMID: 33577831.
Evidence type: Cell study.
Gok M, et al. “Anti-Aging Activity of Syn-Ake Peptide by In Silico Approaches and In Vitro Tests.” Journal of Biomolecular Structure and Dynamics. 2024;42(10):5015–5029. doi:10.1080/07391102.2023.2223681. PMID: 37349941.
Evidence type: Computer modeling and laboratory testing.
Jariwala N, Ozols M, Eckersley A, et al. “Prediction, Screening and Characterization of Novel Bioactive Tetrapeptide Matrikines for Skin Rejuvenation.” British Journal of Dermatology. 2024;191(1):92–106. doi:10.1093/bjd/ljae061. PMID: 38375775.
Evidence type: Computational, cell, and human research on different peptides and formulas.
Farwick M, Grether-Beck S, Marini A, et al. “Bioactive Tetrapeptide GEKG Boosts Extracellular Matrix Formation: In Vitro and In Vivo Molecular and Clinical Proof.” Experimental Dermatology. 2011;20(7):602–604. doi:10.1111/j.1600-0625.2011.01307.x. PMID: 21692860.
Evidence type: Laboratory and human research on a different peptide and formula.
Lupo MP, Cole AL. “Cosmeceutical Peptides.” Dermatologic Therapy. 2007;20(5):343–349. doi:10.1111/j.1529-8019.2007.00148.x. PMID: 18045359.
Evidence type: Review.
Husein El Hadmed H, Fernandez Castillo R. “Cosmeceuticals: Peptides, Proteins, and Growth Factors.” Journal of Cosmetic Dermatology. 2016;15(4):514–519. doi:10.1111/jocd.12229. PMID: 27142709.
Evidence type: Review.
Gorouhi F, Maibach HI. “Role of Topical Peptides in Preventing or Treating Aged Skin.” International Journal of Cosmetic Science. 2009;31(5):327–345. doi:10.1111/j.1468-2494.2009.00490.x. PMID: 19570099.
Evidence type: Review.
Johnson W Jr, Bergfeld WF, Belsito DV, et al. “Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics.” International Journal of Toxicology. 2025;44(2 Suppl):54S–63S. doi:10.1177/10915818251340391.
Halliwell B, Cheah IK, Tang RMY. “Ergothioneine: A Diet-Derived Antioxidant with Therapeutic Potential.” FEBS Letters. 2018;592(20):3357–3366. doi:10.1002/1873-3468.13123. PMID: 29851075.
Evidence type: Review.
Product composition, dual-chamber format, storage instructions, stability, and shelf-life information are based on supplier formulation specifications and stability documentation.
