Ben Greenfield’s longevity skincare protocol
Science-backed ingredients I personally use to support skin health, recovery, and long-term performance
Over the years, I’ve tested nearly every modality and molecule for improving performance, recovery, and healthy aging, not just internally, but at the cellular level across all systems, including the skin.
The truth is, your skin is a high-performance organ. It responds to the same principles that govern muscle recovery, mitochondrial health, and inflammation control.
That’s why I’ve taken the same science-based approach I apply everywhere else and used it to build a skincare protocol focused on one thing: longevity.
what I use daily
why these ingredients matter
What your skin needs to age well, backed by research
As we age, the skin goes through measurable biological shifts:
- NAD+ levels decline
- Mitochondrial function slows
- Oxidative stress increases
- Recovery from UV or treatments becomes delayed
- Collagen and elasticity begin to break down
The right topical ingredients, delivered in the right way, can support skin’s energy metabolism, structural integrity, and long-term resilience.
key ingredients in my protocol
exosomes
Biological messengers that support regeneration
I use exosome-based products to deliver precise signals that activate repair and collagen production. The formula I use — Vampire Exosome® Serum — contains 3 trillion PRP-derived exosomes per bottle, independently tested and quantified.
It helps the skin respond faster, look firmer, and recover more effectively over time.
nad+ apex
Essential for cellular repair and energy metabolism
NAD+ is known for its role in longevity and mitochondrial health. It also plays a critical role in skin barrier function, DNA repair, and post-inflammatory recovery.
I use Young Goose’s NAD+ APEX™ system, found in multiple formulas, to support NAD+ topically in a form the skin can use consistently.
methylene blue
Mitochondrial support and antioxidant defense
Methylene Blue enhances mitochondrial efficiency and reduces oxidative stress. I’ve used it internally for years, and now apply it topically through Blue Peptide Spray — a fast mist I use throughout the day after sun exposure, workouts, flights, or blue light exposure.
spermidine
Supports autophagy and long-term skin renewal
Spermidine supports healthy aging through cellular cleanup and renewal. It helps maintain skin integrity over time.
I apply it at night through Youth Reset, often paired with NAD+ boosters, to help support overnight regeneration and visible skin resilience.
